在心脏传导系统中窦房结的自律性最高,为正常心脏活动的起搏点。多种离子通道参与自动除极是其高自律性的基础。近年来,研究能模拟窦房结功能的生物起搏器成为热点,而对窦房结生理起搏机制的深入了解对此有重要的意义。现就参与窦房结自动除极的离子流及相应离子通道作一简要综述。 In the conduction system of the heart, the highest self-regulation of the sinus node is the pacemaker for normal cardiac activity. A variety of ion channels involved in automatic depolarization is the basis of its high self-discipline. In recent years, it has become a hot topic to study biological pacemakers that can simulate the function of the sinus node. However, deep understanding of the physiological pacing mechanism of the sino-atrial node is of great significance. Now on the participation of automatic depolarization of the sinoatrial node ion current and ion channels for a brief review.