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脑内P物质（SP）能神经元及其轴突末梢和相应受体广泛分布在中央杏仁核（AC）及其投射的重要升压区。本工作显示：（1）谷氨酸（Glu）兴奋AC或将SP分别注入AC投射区：蓝斑（LC）、臂旁核（NPB）、中脑导水管周围灰质（PAG）或外侧下丘脑-穹窿周围区（LH／PF）均引起升压反应；（2）LC，NPB，PAG或LH／PF内预先注入［D－Pro2，D－Phe7，D－Trp9］－SP（SP拮抗剂）均能衰减谷氨酸兴奋AC引起的升压反应；（3）延髓头瑞腹外侧区（RVLM）内预先分别注射酚妥拉明、心得安或阿托品也能削弱AC升压反应，但GDEE（Glu拮抗剂）预处理无此效应。以上结果结合以往报道（LC由RVLM内α－，β-，M-受体，NPB由RVLM内α-受体，PAG则由RVLM内α-和β-受体介导其升压反应）表明AC发出的SP能投射纤维可直接作用于脑干升压区（LC，NPB，PAG）－RVLM升压系统，也可作用于LH／PF，进而实现其升压反应。
Brain substance P (SP) can neurons and their axons and their corresponding receptors are widely distributed in the central amygdala (AC) and its projection of an important area of ?? pressure. This work shows that: (1) glutamate (Glu) is excited by AC or injected SP respectively into the AC projection areas: locus coeruleus (LC), parabrachial nucleus (NPB), periaqueductal gray (PAG) or lateral hypothalamus (LH / PF) induced vasoreaction; (2) pretreatment with [D-Pro2, D-Phe7, D-Trp9] -SP (SP antagonist) in LC, NPB, (3) Preinjection of phentolamine, propranolol or atropine into the rostral ventrolateral medulla (RVLM) can also attenuate the AC step-up response, but GDEE ( Glu antagonist) pretreatment without this effect. These results, combined with previous reports that LC is produced by alpha-, beta-, M-receptors in RVLM, alpha-receptors in RVLM by NPB, and PAG-mediated upregulation of alpha- and beta-receptors in RVLMs The SP projection fibers emitted by AC can act directly on the pressure regrowth region of brain stem (LC, NPB, PAG) -RVLM, and also act on LH / PF to achieve its pressure-rising response.