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目的探讨盐酸溴己新葡萄糖注射液治疗小儿支气管肺炎的临床效果。方法选择2008年1月—2012年12月收治的小儿支气管肺炎患者800例,随机分为对照组320例与治疗组480例。对照组给予吸痰、氧疗、雾化吸入、补液、抗感染等对症治疗,治疗组在对照组基础上给予盐酸溴己新葡萄糖注射液100 ml静脉滴注,1次/d(病情较严重者可1-2次/d),治疗7 d后比较两组临床疗效和不良反应。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果总有效率对照组83.75%,治疗组98.33%,两组比较差异有统计学意义(χ2=58.859,P<0.05)。对照组无不良反应发生,治疗组腹泻8例,恶心14例,停药或减量后不良反应消失。结论盐酸溴己新葡萄糖注射液治疗小儿支气管肺炎,效果显著,但在使用时应注意不良反应。
Objective To investigate the clinical effect of bromhexine hydrochloride dextrose injection on bronchial pneumonia in children. Methods 800 children with bronchopneumonia admitted in our hospital from January 2008 to December 2012 were randomly divided into control group (320 cases) and treatment group (480 cases). Patients in the control group were given symptomatic treatment such as suctioning, oxygen therapy, nebulization, rehydration, anti-infection and so on. The treatment group was given Bromhexine Hydrochloride Injection 100 ml intravenously on the basis of the control group, once per day Who can be 1-2 times / d), after 7 days of treatment compared the clinical efficacy and adverse reactions in both groups. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The total effective rate was 83.75% in the control group and 98.33% in the treatment group. There was significant difference between the two groups (χ2 = 58.859, P <0.05). In the control group, no adverse reactions occurred. In the treatment group, there were 8 cases of diarrhea and 14 cases of nausea. Adverse reactions disappeared after withdrawal or dose reduction. Conclusion bromhexine hydrochloride glucose injection in children with bronchial pneumonia, the effect is significant, but should pay attention to the use of adverse reactions.