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目的 :探讨缓解期慢性阻塞性肺病 (COPD)患者的室性心律失常与夜间低氧血症及睡眠时相的关系。方法 :选择缓解期COPD患者 2 2例 ,男 18例 ,女 4例 ,正常对照组 12例 ,男 8例 ,女 4例 ,AHI <10。被检查者至少进行一次整夜多导睡眠仪监测 ,计算机回放检索室性异位搏动发生时的血氧饱和度及睡眠时相。结果 :COPD组夜间室性异位搏动的发生率为 5 9 1% (13/2 2 ) ,明显高于正常组 8 2 % (1/12 ) (P <0 .0 1)。夜间室性异位搏动的发生与夜间血氧饱和度降低无相关性 ,不同睡眠时相中室性异位搏动的发生频率无差别。结论 :慢性阻塞性肺病患者轻—中度夜间低氧血症和睡眠时相对夜间室性异位搏动事件无明显影响。
Objective: To investigate the relationship between ventricular arrhythmia and nocturnal hypoxemia and sleep time in patients with chronic obstructive pulmonary disease (COPD) during remission. Methods: Twenty-two COPD patients were selected, including 18 males and 4 females, and 12 normal controls. There were 8 males and 4 females with AHI <10. At least one overnight polysomnography was performed on the subjects under test and computerized tomography was used to retrieve the oxygen saturation and sleep phase at the time of ventricular ectopic beating. Results: The incidence of ventricular ectopic beats at night was 591% (13/2 2) in COPD group, which was significantly higher than that in control group (82% 1/12) (P <0.01). There was no correlation between nocturnal ventricular ectopic beats and nocturnal oxygen saturation. There was no difference in the frequency of ventricular ectopic beats at different phases of sleep. CONCLUSIONS: There is no significant effect of mild to moderate nocturnal hypoxemia and relative nighttime ventricular ectopic beats in patients with chronic obstructive pulmonary disease.