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近来报导造影前给予皮质醇防止造影剂反应的文章引起了很多放射学者的兴趣,许多研究所用盲法随机比较了两种口服皮质醇方法,一种方法是给予双剂量,造影前12和2h均给予32mg甲基强的松龙(methylprednisolone);另一种方法是仅在造影前2h给予单剂数(32mg甲基强的松龙),以及相应的给予安慰剂方法。据根告,静脉注射离子型造影剂以前12～24h给予皮质醇能够防止离子型造影剂的全身毒性。与接受非离子型造影剂而没作前处理的需要立即治疗的反应率相比,前者没有超过后者。给予单剂量和安慰剂均未提供这种保护
Recently articles that reported the administration of cortisol to prevent contrast before angiography aroused much interest among radiologists. Many studies used a randomized blind trial comparing two oral cortisol methods. One was to administer a double dose, 12 and 2 h before angiography Administered with 32 mg of methylprednisolone; another approach was to administer a single dose (32 mg of methylprednisolone) only 2 h prior to angiography and the corresponding placebo approach. According to the report, intravenous ionizing contrast agent given before 12 ~ 24h cortisol to prevent the ionic toxicity of the contrast agent. The former did not surpass the latter in response to the need for immediate treatment with non-ionic contrast agents without pretreatment. Neither single dose nor placebo provided this protection