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目的:探讨比索洛尔联合坎地沙坦治疗充血性心力衰竭(CHF)的疗效。方法:将200例CHF患者随机分为治疗组和对照组,治疗组在对照组基础上加用比索洛尔和坎地沙坦,疗程为6个月。分别于用药前及给药6个月后测定血浆BNP浓度、LVEF(心脏射血分数)、FS(左室短轴缩短率)。结果:治疗组EF、FS改善(P均<0.01),BNP浓度显著降低(P<0.01)。结论:比索洛尔联合坎地沙坦可改善CHF患者的心功能,显著降低血浆BNP浓度,对治疗充血性心力衰竭疗效很好。
Objective: To investigate the efficacy of bisoprolol combined with candesartan in the treatment of congestive heart failure (CHF). Methods: 200 CHF patients were randomly divided into treatment group and control group. The treatment group was given bisoprolol and candesartan on the basis of the control group. The course of treatment was 6 months. Plasma BNP concentration, LVEF (ejection fraction) and FS (shortening of left ventricular fraction) were measured before administration and 6 months after administration. Results: The EF and FS of the treatment group were improved (all P <0.01), and the BNP concentration was significantly lower (P <0.01). CONCLUSIONS: Bisoprolol combined with candesartan improves cardiac function in patients with CHF, significantly decreases plasma BNP levels, and works well for the treatment of congestive heart failure.