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采用免疫组化ＡＢＣ法对８２例髓母细胞瘤（ＭＢ）进行中间丝蛋白（ＧＦＡＰ、ＮＦ、Ｖｉｍ）和神经内分泌标志物（ＳＹＮ、ＣｇＡ）检测。结果显示ＭＢ８２例中，ＧＦＡＰ阳性７４例（９０．２４％）、ＮＦ阳性１７例（２０．７３％）、Ｖｉｍ阳性３３例（４０．２４％）、ＳＹＮ阳性６２例（７５．６１％）、ＣｇＡ阳性２２例（２６．８３％）。有８例肿瘤５种标志物均有表达，其余也有２种或２种以上标志物表达。标志物表达与患者年龄、性别、肿瘤大小、分化及预后等因素之间无关（Ｐ皆＞０．０５）。提示髓母细胞瘤是具有不同中间丝蛋白及神经内分泌标志物表达的异质性肿瘤。这种表达可能是幼稚的原始神经外胚层组织胚胎发育过程中标志物表达的重演。
Using immunohistochemical ABC method, 82 cases of medulloblastoma (MB) were examined for intermediate filament protein (GFAP, NF, Vim) and neuroendocrine markers (SYN, CgA). The results showed that of the 82 patients with MB, 74 (90.24%) were GFAP positive, 17 (20.73%) were NF positive, 33 (40.24%) were Vim positive, and 62 (75.61%) were SYN positive. CgA positive in 22 cases (26.83%). There were 8 tumors with 5 markers all expressed, and the rest also had 2 or more markers. There was no relationship between the expression of markers and the age, sex, tumor size, differentiation and prognosis of patients (P all >0.05). It is suggested that medulloblastoma is a heterogeneous tumor with different intermediate silk proteins and neuroendocrine markers. This expression may be a reappearance of marker expression in naive primitive neuroectodermal tissue during embryonic development.