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目的 :为了探讨自体脾组织片移植对荷瘤机体抗肿瘤免疫功能影响。方法 :我们用 S1 80 瘤株制备了荷瘤动物模型 ,以模拟脾切除组和脾切除组为对照 ,以巨噬细胞吞噬功能、外周血 T淋巴细胞亚群测定、血清白细胞介素 - 2含量测定、肿瘤重量测定 ,对自体脾组织移植的抗肿瘤作用进行观察。结果 :自体脾组织移植组的抗肿瘤功能与模拟脾切除组相比 ,无显著差异(P>0 .0 5 ) ;与脾切除组相比差异显著 (P <0 .0 5 )。结论 :自体移植脾组织存活后 ,其抗肿瘤免疫功能与正常脾功能相比无显著差异。自体脾组织移植是脾切除后弥补脾功能的有效办法。
Objective: To investigate the effect of autologous spleen tissue graft on anti-tumor immune function of tumor-bearing mice. Methods: The tumor - bearing animal model was established by using S180 tumor strain. The spleen resection group and the splenectomy group were used as control. The phagocytosis of macrophages, the determination of T - lymphocyte subsets in peripheral blood, the levels of serum interleukin - Determination, determination of tumor weight, the anti-tumor effect of autologous spleen transplantation were observed. Results: Compared with the splenectomy group, the anti-tumor function of the splenic tissue transplantation group had no significant difference (P> 0.05). Compared with the splenectomy group, there was significant difference (P <0.05). Conclusion: There is no significant difference in anti-tumor immune function compared with normal spleen function after the autologous transplantation of spleen tissue. Autologous spleen tissue transplantation is spleen resection to make up for an effective method of spleen function.