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目的：观察瑞芬太尼在应用于介入手术的效果。方法收集介入手术的患者60例，随机分为瑞芬太尼和芬太尼两组，瑞芬太尼组应用瑞芬太尼和丙泊酚，芬太尼组应用芬太尼和丙泊酚，对比分析两组用药后的心率、血压、不良反应等，监测并记录患者的苏醒时间。结果瑞芬太尼和芬太尼两组一般情况以及手术时间都无显著差异（P>0.05）；两组低血压及心动过缓发生率两组间的比较具有统计学差异（P<0.05）；瑞芬太尼组苏醒时间显著短于芬太尼组，术后 DSST评分显著高于芬太尼组（P<0.05）；瑞芬太尼组用药量显著少于芬太尼组[1]（P0.05);In the two groups the incidence of hypotension and bradycardia the comparison between the two groups have statistical dif erence (P<0.05);Rui fentanyl group wake times significantly shorter than fentanyl group,postoperative DSST score significantly higher than that of fentanyl group (P<0.05);Ray dose fentanyl group was significantly less than fentanyl group (P<0.05);Two groups of postoperative adverse reactions were observed.Conclusion:red fentanyl waking time short and enhanced the DSST response rates,postoperative recovery ef ect is bet er also,suitable for smal incision wounds, pain,time is short and there is no resistance to the clinical application of interventional surgery.