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目的:探究重庆地区6个月~2岁儿童血清甲胎蛋白(AFP)水平及性别差异,确定不同年龄段的参考值范围。方法:选取418例健康儿童并采集静脉血,用化学发光法定量测定血清中的AFP含量,并对检测结果进行统计学分析。结果:418例儿童按年龄分4组,各组间AFP测定结果比较差异具有统计学意义(P<0.01);1.5~2岁组与成人比较差异无统计学意义;分性别进行比较,各年龄组男女之间比较均无统计学意义(P>0.05);重庆地区6个月~2岁儿童血清AFP参考值范围为6~9个月组<42.04 ng/mL,>9~12个月组<15.13 ng/mL,>1~1.5岁组<9.50 ng/mL,>1.5~2岁组<7.25 ng/mL。结论:健康儿童血清AFP水平随年龄增长呈递减趋势,1岁6个月后接近成人水平,男女之间无性别差异;不同实验室宜根据环境及自身条件制定不同年龄段的AFP参考值范围,诊断相关疾病时宜参考本地区儿童AFP正常参考值。
Objective: To explore the level of AFP and sex differences in children aged 6 months to 2 years in Chongqing and to determine the reference range of different age groups. Methods: 418 healthy children were selected and venous blood was collected. The AFP content in serum was determined by chemiluminescence and the results were statistically analyzed. Results: A total of 418 children were divided into 4 groups according to age. There was significant difference in AFP between groups (P <0.01). There was no significant difference between 1.5 and 2 years old group and adults. There was no significant difference between men and women (P> 0.05). The AFP values of children aged 6 months to 2 years in Chongqing ranged from 42.04 ng / mL for 6-9 months to> 9-12 months <15.13 ng / mL,> 9.50 ng / mL for> 1 to 1.5 years and <7.25 ng / mL for> 1.5 to 2 years of age. Conclusions: Serum AFP level of healthy children shows a decreasing trend with age, and close to the adult level after 6 months of age. There is no gender difference between men and women. Different laboratories should set AFP reference range of different age groups according to the environment and their own conditions, Should be related to the diagnosis of disease-related reference to the local AFP normal reference value of children.