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目的:探讨异丙酚麻醉用于早孕患者人工流产手术时对患者NO含量和NOS活力的影响。方法:将20例妊娠44天患者随机分为异丙酚麻醉组(P组)和对照组(C组),每组10例。P组采用异丙酚静脉全身麻醉,C组自愿选择不用任何麻醉方法。术前和术毕取患者静脉血,分别用硝酸还原酶法和化学法测定血清NO含量和NOS活力。结果:C组术毕NO含量为(135.22±27.68)μmol/L,高于术前〔(105.98±22.13)μmol/L〕,差异有统计学意义(P<0.05),术毕NOS活力也高于术前,差异有统计学意义(P<0.05)。与C组相比,P组术毕NO含量和NOS活力均低于C组,差异有统计学意义(P<0.05)。结论:异丙酚麻醉可以降低手术疼痛引起的NOS活性升高及NO合成增加。早孕人工流产应采用异丙酚静脉麻醉为主的方法。
Objective: To investigate the effect of propofol anesthesia on NO content and NOS activity in patients with early pregnancy induced abortion. Methods: Twenty cases of pregnancy 44 days were randomly divided into propofol anesthesia group (P group) and control group (C group), 10 cases in each group. P group with propofol intravenous general anesthesia, C group voluntary choice without any anesthesia. Preoperative and postoperative patients with venous blood taken, respectively, nitrate reductase and chemical determination of serum NO content and NOS activity. Results: The NO level in group C was (135.22 ± 27.68) μmol / L, higher than that in preoperative 〔(105.98 ± 22.13) μmol / L〕, the difference was statistically significant (P0.05) Before operation, the difference was statistically significant (P <0.05). Compared with group C, the NO content and NOS activity in group P were lower than those in group C, with a significant difference (P <0.05). CONCLUSIONS: Propofol anesthesia can reduce the increase of NOS activity and NO synthesis induced by surgical pain. Induced abortion early pregnancy should be based on intravenous propofol anesthesia-based approach.