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目的:探讨雷公藤多甙、沙利度胺、小剂量糖皮质激素、秋水仙碱及硫唑嘌呤治疗白塞病的临床效果。方法:总结分析17例白塞病患者使用雷公藤多甙、沙利度胺、小剂量糖皮质激素、秋水仙碱及硫唑嘌呤治疗的临床资料。结果:5例患者经此方案治疗后,随访8个月未复发。其中,2例病情严重,曾在外院以大剂量糖皮质激素联合环磷酰胺冲击治疗后,仍反复发病的患者,给予维持治疗;3例患者仅维持治疗2个月。12例患者经此方案治疗后,能缓解,但随访期间仍反复发病。其中6例持续维持治疗,6例症状缓解,经维持治疗2周左右,自行停药。结论:糖皮质激素是治疗白塞病最常用的西药。沙利度胺及秋水仙碱、免疫抑制剂(环孢素及硫唑嘌呤)也在临床上被应用治疗白塞病多年,临床疗效明显。
Objective: To investigate the clinical effects of Tripterygium glycosides, thalidomide, low dose glucocorticoid, colchicine and azathioprine in the treatment of Behcet’s disease. Methods: The clinical data of 17 patients with Behcet’s disease treated with tripterygium glycosides, thalidomide, low dose glucocorticoid, colchicine and azathioprine were summarized and analyzed. Results: Five patients did not relapse after 8 months of follow-up after treatment with this regimen. Among them, 2 patients were in serious condition. Patients who had recurrent disease were treated with high-dose glucocorticoid plus cyclophosphamide in the outpatient department and were given maintenance treatment. Only 3 patients were treated for 2 months. Twelve patients were relieved after treatment with this regimen, but recurrence was still found during follow-up. Among them, 6 patients continued to maintain the treatment, and 6 patients relieved their symptoms. After stopping the treatment for about 2 weeks, they stopped their own treatment. Conclusion: Glucocorticoids are the most commonly used western medicine in the treatment of Behcet’s disease. Thalidomide and colchicine, immunosuppressive agents (cyclosporine and azathioprine) are also clinically used for the treatment of Behcet’s disease for many years, the clinical curative effect is obvious.