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在恶性肿瘤和一些自身免疫性疾病的治疗中 ,化疗是必不可少的治疗措施 ,但研究发现化疗药物对男性睾丸生精功能损害极大 ,可部分或全部杀死各级生精细胞 ,使男性精子数量减少和 /或精子活力降低 ,甚至不育。研究发现在化疗的不同时期应用不同的性激素可保护睾丸生精功能。近年来对睾酮和雌激素、促性腺激素释放激素类似物或激动剂、雄激素拮抗剂、促性腺激素释放激素 拮抗剂在化疗中对睾丸生精功能的保护及机理进行了较多的研究 ,并取得一定的成绩。
In the treatment of malignant tumors and some autoimmune diseases, chemotherapy is an indispensable treatment, but the study found that chemotherapy drugs on the male testicular spermatogenic damage great, can be partially or completely kill spermatogenic cells at all levels, so that Men reduce the number of sperm and / or reduce sperm motility, or even infertility. The study found that the application of different sex hormones in different periods of chemotherapy can protect the testicular spermatogenic function. In recent years, more attention has been paid to the protection and mechanism of testicular steroid and estrogen, gonadotropin-releasing hormone analogues or agonists, androgen antagonists and gonadotropin-releasing hormone antagonists in the chemotherapy, And achieved some results.