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背景和目的:非酒精性脂肪性肝炎(NASH)是一种进展性肝脏疾病,表现为脂肪变性,炎症浸润和纤维化。在NASH病程中,胰岛素抵抗为其共同特征。NASH的分子机制包括2个步骤:胰岛素抵抗情况下肝细胞内甘油三酯的堆积和活性氧簇引发的氧化应激反应的增强。
Background and Objective: Non-alcoholic steatohepatitis (NASH) is a progressive liver disease characterized by steatosis, inflammatory infiltration and fibrosis. In the course of NASH, insulin resistance is their common feature. The molecular mechanism of NASH consists of two steps: the accumulation of triglycerides in hepatocytes and the increase in oxidative stress induced by reactive oxygen species in the case of insulin resistance.