氯仿的毒性及车间卫生标准研究

来源 :中华劳动卫生职业病杂志 | 被引量 : 0次 | 上传用户:thonny007
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我国氯仿职业接触人群主要分布于有机玻璃粘合、有机物萃取和致冷剂合成作业。在无通风排毒设备条件下,作业点空气中氯仿浓度范围为4.27~147.91mg/m~3。调查表明,长期接触29.51mg/m~3可致接触者出现乏力、嗜唾、心悸等不适症状,肝脏蛋白合成功能受到一定影响;接触者消极性情感明显增强,注意力、记忆能力、感知能力和反应速度受到影响。雄性大鼠亚急性吸入592mg/m~3氯仿后肝脏发生可逆性功能变化。据此,提出氯仿的最高容许浓度建议值为20mg/m~3。‘ China’s occupational exposure to chloroform are mainly distributed in plexiglass bonding, organic extraction and refrigerant synthesis operations. Under the condition of ventilation and detoxification equipment, the concentration of chloroform in the air at work point ranged from 4.27 to 147.91 mg / m ~ 3. The survey showed that long-term exposure to 29.51mg / m ~ 3 can cause contact with patients with fatigue, sphincter, palpitations and other symptoms, liver protein synthesis is affected to some extent; contact negative emotions significantly increased, attention, memory, and cognitive abilities And the reaction speed is affected. After subacute inhalation of male rats with 592mg / m ~ 3 chloroform reversible changes in liver function. Accordingly, the proposed maximum allowable concentration of chloroform suggested 20mg / m ~ 3. ’
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