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目的:探讨硫酸镁联合硝苯地平控释片治疗妊高征的临床疗效。方法:本次研究的90例妊高征患者均为我院在2012年9月到2014年10月期间收治,将其按照治疗方式的不同分为观察组45例和对照组45例,观察组采用硫酸镁联合硝苯地平控释片治疗,对照组患者单纯采取硫酸镁治疗,对比两组患者的治疗效果、血粘度改善情况和血压控制水平。结果:观察组治疗总有效率为97.78%,平均血粘度为(2.01±0.13)m Pa·s,舒张压与收缩压分别为(95.24±1.93)mm Hg和(146.82±4.73)mm Hg;对照组治疗总有效率为62.22%,平均血粘度为(3.94±1.62)m Pa·s,舒张压与收缩压分别为(114.96±8.76)mm Hg和(166.05±7.94)mm Hg。两组治疗总有效率、血粘度和血压控制水平比较差异有统计学意义(P<0.05)。结论:硫酸镁联合硝苯地平控释片治疗妊高征的临床疗效显著,可有效改善患者血粘度,无不良反应,安全性高,值得在临床上推广使用。
Objective: To investigate the clinical efficacy of magnesium sulfate combined with nifedipine controlled release tablets in the treatment of pregnancy induced hypertension. Methods: All the 90 PIH patients in our study were admitted to our hospital from September 2012 to October 2014. They were divided into observation group (45 cases) and control group (45 cases) according to different treatment methods. Observation group Using magnesium sulfate combined with nifedipine controlled release tablets, patients in the control group were treated with magnesium sulfate alone. The therapeutic effect, blood viscosity improvement and blood pressure control were compared between the two groups. Results: The total effective rate of observation group was 97.78%, mean blood viscosity was (2.01 ± 0.13) mPa · s, diastolic and systolic pressures were (95.24 ± 1.93) mm Hg and (146.82 ± 4.73) mm Hg, respectively The total effective rate was 62.22%. The average blood viscosity was (3.94 ± 1.62) mPa · s, and the diastolic and systolic pressures were (114.96 ± 8.76) mm Hg and (166.05 ± 7.94) mm Hg, respectively. The total effective rate of treatment, blood viscosity and blood pressure control level difference was statistically significant (P <0.05). Conclusion: The clinical efficacy of magnesium sulfate combined with nifedipine GITS in the treatment of PIH is significant, which can effectively improve the blood viscosity, no adverse reactions and high safety. It is worth to be used clinically.