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目的：探讨一氧化氮（ＮＯ）和内皮素（Ｅｎｄｏｔｈｅｌｉｎ，ＥＴ）在妊高征发病中的变化及其病理意义。方法：用分光光度法和放射免疫法分别定量检测正常妊娠３０例（对照组）和妊高征３７例（妊高征组）血浆ＮＯ和ＥＴ的变化。结果：妊高征组血浆ＮＯ水平低于对照组（Ｐ＜０．０１），ＥＴ水平则高于对照组（Ｐ＜０．０１）；妊高征组分娩前后相比，ＮＯ水平分娩后升高（Ｐ＜０．０１），ＥＴ水平则下降（Ｐ＜０．０１），ＮＯ、ＥＴ呈显著负相关（Ｐ＜０．０１），ＮＯ、ＥＴ与平均动脉压均有显著相关性（Ｐ＜０．０１）。结论：ＮＯ与ＥＴ在妊高征的发病机制中有重要作用，ＥＴ／ＮＯ失衡可以反映妊高征的病变程度，其病理变化在某种程度上呈可逆性。
Objective: To investigate the changes and pathological significance of nitric oxide (NO) and endothelin (ET) in the pathogenesis of PIH. Methods: The levels of plasma NO and ET were measured by spectrophotometry and radioimmunoassay in 30 normal pregnant women and 37 pregnant women with PIH. Results: The plasma levels of NO in PIH group were significantly lower than those in control group (P <0.01), while the levels of ET in PIH group were higher than those in control group (P <0.01) (P <0.01), ET level decreased (P <0.01), NO, ET was significantly negative correlation (P <0.01), NO, ET and mean arterial pressure were significantly correlated <0.01). CONCLUSION: NO and ET play an important role in the pathogenesis of PIH. The imbalance of ET / NO can reflect the severity of PIH. The pathological changes are reversible to a certain extent.