论文部分内容阅读
目的 对鼻咽癌和食管癌PCNA、P53、P21及C—erbB—2表达的对比分析,为两种肿瘤在临床放疗技术的相互借鉴提供参考依据。方法 用许氏ABC免疫组化法对未受过针对肿瘤治疗的鼻咽鳞癌39例和同期食管鳞癌49例进行PCNA、P53、P21及C—erbB—2表达的对比分析研究。结果 鼻咽癌的PCNA、P53、P21及C—erbB—2的阳性表达率分别为94.7％(36/38)、71.8％(28/39)、53.9％(21/38)、64.9％(24/37);在食管癌方面分别为91.7％(44/48)、54.2％(26/48)、44.9(22/49)、45.8％(22/48)。统计学检验,两种肿瘤的阳性表达率无明显差异。在表达强度方面,鼻咽癌的PCNA明显大于食管癌的PCNA,但其余三个指标的表达强度在两类肿瘤中无明显差异。结论 两种肿瘤的细胞增殖状态有类似规律,但又不尽相同。以上结果为食管癌和鼻咽癌放疗技术的相互借鉴提供参考依据。
Objective To compare the expression of PCNA, P53, P21 and C-erbB-2 in nasopharyngeal carcinoma and esophageal carcinoma, and to provide a reference for the mutual reference of clinical and radiotherapy techniques between the two tumors. METHODS: The expression of PCNA, P53, P21 and C-erbB-2 in nasopharyngeal squamous cell carcinoma (39 cases) and esophageal squamous cell carcinoma (49 cases) were analyzed by ABC’s immunohistochemical ABC method. Results The positive rates of PCNA, P53, P21 and C-erbB-2 in nasopharyngeal carcinoma were 94.7% (36/38), 71.8% (28/39), 53.9% (21/38) and 64.9% / 37); in esophageal cancer, 91.7% (44/48), 54.2% (26/48), 44.9 (22/49) and 45.8% (22/48), respectively. Statistical tests showed no significant difference in the positive rates of the two tumors. In terms of expression intensity, PCNA of NPC was significantly higher than that of PCNA of esophageal cancer, but the intensity of expression of the other three indicators had no significant difference between the two types of tumors. Conclusion The cell proliferation status of the two tumors has a similar pattern, but not the same. The above results provide references for the mutual reference of esophageal and nasopharyngeal carcinoma radiotherapy techniques.