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目的:分析研究治疗排卵障碍性不孕在不同时期采用克罗米酚的临床疗效。方法:收取2010年2月-2011年4月在我院患有排卵障碍性不孕的病人共80例随机分为两组:实验组40例和对照组40例。实验组在月经周期开始的一天就服用克罗米酚胶囊,50mg.d-1,连续使用五天,对照组在月经周期的第五天开始服用这类药物,50mg.d-1,连续使用五天,如果没有出现妊娠反应,在下一个月经周期采用同一方法治疗。观察两组的排卵之前的卵泡数量、最大的卵泡直径,子宫内膜的厚度、受孕率、排卵率。结果:平均的卵泡数量(直径>14mm的卵泡个数)实验组明显少于对照组,最大卵泡直径,实验组>对照组,差异具有显著性;子宫内膜的厚度,实验组>对照组,差异具有显著性;排卵率,实验组和对照组差异不具有显著性;妊娠率,实验组>对照组,差异具有显著性;结论:在整个月经周期的初期即第1天到第5天使用克罗米酚用于治疗排卵障碍性不孕,可以使妊娠率显著提高,具有临床推广价值应用。
Objective: To analyze the clinical efficacy of clomiphene in treatment of ovulatory dysplasia at different periods. Methods: A total of 80 patients with infertility due to anovulatory disorder in our hospital from February 2010 to April 2011 were randomly divided into two groups: 40 in experimental group and 40 in control group. The experimental group took clomiphene capsules 50mg.d-1 on the day of the beginning of the menstrual cycle for five consecutive days. The control group started taking these drugs on the fifth day of the menstrual cycle, 50mg.d-1, continuous use Five days, if there is no pregnancy reaction, in the next menstrual cycle using the same method of treatment. The number of follicles before ovulation, the largest diameter of follicles, the thickness of endometrium, the rate of conception and ovulation were observed. Results: The average number of follicles (the number of follicles with diameter> 14mm) in the experimental group was significantly less than that in the control group, the largest follicle diameter, the experimental group> the control group, the difference was significant; the thickness of the endometrium, the experimental group> the control group, The difference was significant; ovulation rate, the experimental group and the control group, the difference was not significant; pregnancy rate, experimental group> control group, the difference was significant; Conclusion: the first menstrual cycle in the first day to the fifth day Clomiphene for the treatment of ovulation disorders infertility, pregnancy rates can be significantly improved, with the clinical application of value.