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目的：探讨经心房内迷宫式射频消融术治疗心房颤动（房颤）的可行性。方法：健康杂种犬１８只，电极导管标记心房及心耳各部位后进行连续性线性消融。急性组（１２只）和慢性组（６只）分别于术前及术后即刻和术后１个月时观察心脏电生理变化及房颤诱发率；急性组观察心房和瓣膜、冠状动脉损伤情况。结果：射频消融术后各项电生理指标无显著变化（Ｐ＞０．０５）；术前全部犬均能诱发出暂时性房颤和持续性房颤。术后急性组和慢性组暂时性房颤（１，０）和低浓度乙酰甲胆碱（Ｍｅｔｈａｃｈｏｌｉｎｅ）静脉滴注时持续性房颤（２，０）的诱发犬数显著降低（Ｐ＜０．０５）；急性组无心房穿孔和瓣膜、冠状动脉损伤。结论：本方法可以达到治疗房颤的目的，值得进一步研究。
Objective: To investigate the feasibility of atrial maze radiofrequency ablation in the treatment of atrial fibrillation (AF). Methods: Eighteen healthy mongrel dogs were treated with continuous catheter ablation of atrial and atrial appendage after catheterization. Acute group (12 rats) and chronic group (6 rats) were observed before and after surgery and 1 month after surgery, respectively, the electrophysiological changes and the induction rate of atrial fibrillation; acute group observed atrial and valve, coronary artery injury . Results: There was no significant change in electrophysiological indexes after radiofrequency ablation (P> 0.05). All dogs were able to induce temporary atrial fibrillation and persistent atrial fibrillation before operation. Postoperative acute atrial fibrillation (1.0) and chronic amebic group (1.0) and low concentration of methacholine (Methacholine) intravenous infusion of persistent atrial fibrillation (2,0) induced significantly reduced the number of dogs (P <0. 05); acute group without atrial perforation and valve, coronary artery injury. Conclusion: This method can achieve the purpose of treatment of atrial fibrillation, it is worth further study.