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目的:研究脊髓型多发性硬化(SMS)是否存在脑白质损伤。方法:对25例SMS患者和35例正常志愿者行常规MRI和DTI检查,分割提取脑白质后,研究SMS患者脑白质平均弥散率(MD)和分数各向异性(FA)直方图的异常变化。结果:同正常志愿者比较,SMS患者脑白质的平均MD增高(P=0.005),平均FA降低(P=0.001)和MD直方图峰位置降低(P=0.007)。在SMS患者,脑白质MD直方图峰高与扩展残疾状态评分(EDSS)中度相关(r=0.453,P=0.023)。结论:SMS患者脑白质存在损伤,脑白质MD直方图峰高可用于监测SMS患者的临床进展。
Objective: To investigate whether there is white matter damage in spinal cord multiple sclerosis (SMS). Methods: 25 cases of SMS patients and 35 normal volunteers underwent routine MRI and DTI examination. After the white matter was separated and extracted, the abnormal changes of white matter average diffusivity (MD) and fractional anisotropy (FA) histogram were studied in SMS patients. . Results: Compared with normal volunteers, the mean MD of white matter in patients with SMS increased (P = 0.005), the average FA decreased (P = 0.001) and the peak position of MD histogram decreased (P = 0.007). In SMS patients, the white matter MD histogram peak height was moderately associated with Extended Disability Status Score (EDSS) (r = 0.453, P = 0.023). Conclusion: There is impairment of white matter in SMS patients. The peak height of white matter histogram may be used to monitor the clinical progress of SMS patients.