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树突状细胞(dendriticcells,DC)是由抗原递呈细胞家族组成,分布于除脑和睾丸以外身体各部的任何组织。DC能捕获细菌、病毒等抗原,并递呈给次级淋巴器官的T细胞,是天然免疫和适应性免疫连接的一个重要纽带。DC既能诱导初级免疫反应,又能诱导次级免疫反应,是启动、调控、并维持免疫应答的中心环节,是目前发现的功能最强的抗原提呈细胞。DC通过受体的方式摄取外来抗原,并能与这些抗原表面的MHCI类和Ⅱ类分子结合,刺激初始型CD_8~+T细胞和CD_4~+T细胞活化。DC除了诱导抗原特异性细胞毒性T淋巴细胞外,
Dendritic cells (DCs) are made up of a family of antigen-presenting cells that distribute in any part of the body other than the brain and testis. DC can capture bacteria, viruses and other antigens, and presented to secondary lymphoid organ T cells, is an important link between innate immunity and adaptive immunity. DC can not only induce primary immune response, but also induce secondary immune response, which is the central link of initiation, regulation and maintenance of immune response, and is the strongest antigen-presenting cell currently found. DCs take up the extraneous antigens through the receptor and can combine with MHC class I and II molecules on the surface of these antigens to stimulate the activation of naive CD_8 ~ + T cells and CD_4 ~ + T cells. DC, in addition to inducing antigen-specific cytotoxic T lymphocytes,