同批断乳两周的Wistar雄性大鼠 59只 ,随机分为 3个组 ,用同一病家的高岭土拌煤烘干与柴烘玉米加入配合饲料喂养。饲料含氟、铝 3 9× 10 - 6 ,12 4× 10 - 6 ;10 7× 10 - 6 ,4 0 4×10 - 6 ;2 12 ,6 6 8× 10 - 6 。实验 11、 2 0周分两批股动脉放血处死。检测了大鼠骨、脑、血、尿中多种元素。结果表明 ,血清钙一直较高 ,磷降低。实验 11周 ,Ⅱ、Ⅲ组骨氟分别增高 6、 10倍 ,尿氟增高 4、 6倍 ;骨、脑、全血铝均随摄氟、铝量的增多而递减 ,尿铝递增。尿中其它元素多一直减少。骨中金属元素随骨铝的递减而递减。Ⅱ组全血锌显著下降。实验 2 0周 ,Ⅱ、Ⅲ组骨氟是Ⅰ组的 3 5和 8 2倍 ,为实验 11周时的 58 1%和 80 7% ;尿氟是 1 4和 3倍。骨、脑铝随氟、铝摄入量的递增而递增 ,骨中金属元素含量也随之递增 ,骨磷降低。全血磷递增 ,锌均升高。本实验多元素含量由低向高变化的逆反过程与骨软化向硬化的病理转换相吻合 ;铝和氟彼此可影响对方的体内过程和在骨骼中的蓄积并引起多元素含量和相关性的显著变化。提示消化道内源性无机盐排泄过多 ;低龄动物的骨、脑对铝有排斥反应 ,但有铝危害表现 Fifty-nine Wistar rats with the same weaning were randomly divided into three groups, fed with compound feed with kaolin mixed with coal and dried with firewood and corn with the same disease. The feed contains fluorine, aluminum 3 9 × 10 - 6, 12 4 × 10 - 6; 10 7 × 10 - 6, 4 0 4 × 10 - 6; 2 12, 6 6 8 × 10 - 6. Experiment 11, 20 weeks two batches of femoral artery were sacrificed. A variety of elements in rat bone, brain, blood and urine were detected. The results showed that serum calcium has been higher, phosphorus decreased. In the 11th week of experiment, bone fluoride in group Ⅱ and group Ⅲ increased by 6 times and 10 times and urinary fluoride increased by 4 and 6 times respectively. Aluminum and aluminum in bone, brain and whole blood decreased with the increase of fluoride and aluminum content, and urinary aluminum increased gradually. Other elements in the urine have been reduced. Bone metal elements with decreasing bone and aluminum decreased. Ⅱ group of whole blood zinc decreased significantly. In experiment 20, the bone fluoridations in groups Ⅱ and Ⅲ were 35 and 82 times higher than those in group Ⅰ, 58 1% and 80 7% respectively at 11 weeks of experiment. Urinary fluorosis was 14 and 3 times higher. Bone and brain aluminum increased with the increasing of fluorine and aluminum intake. The content of metal elements in bone also increased, while the bone phosphorus decreased. Increased whole blood phosphorus, zinc are increased. In this experiment, the reversal process from low to high changes coincided with the pathological transformation from osteomalacia to sclerosis; aluminum and fluoride can affect each other’s in vivo processes and the accumulation in the bones and cause a significant multi-element content and correlation Variety. Prompted endogenous gastrointestinal excretion of digestive tract too much; young animals of the bones, brain rejection of aluminum, but the performance of aluminum