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目的探讨血清HBsAg浓度检测对慢性乙肝患者抗病毒药物治疗效果的预测价值。方法收集2014年6月-2016年6月间本院收治的80例慢性乙肝患者进行研究,对所有患者均采取抗病毒药物治疗,并对患者动态监测血常规、肝常规、肾功能、乙肝五项等相关指标,了解患者HBsAg浓度、HBe Ag定量、HBV-DNA定量等状况。结果 80例患者治疗后完全应答43例、非完全应答37例。完全应答患者HBsAg水平、HBV-DNA水平与非完全应答相比明显较低,(P<0.05)。且HBV-DNA和HBsAg存在正相关。结论血清HBsAg浓度检测可有效预测慢性乙肝患者抗病毒药物治疗效果,血清HBsAg浓度较低患者病毒学应答效果更佳。
Objective To investigate the predictive value of serum HBsAg detection in the treatment of chronic hepatitis B patients with antiviral drugs. Methods Eighty patients with chronic hepatitis B who were admitted to our hospital from June 2014 to June 2016 were enrolled in this study. All patients were treated with antiviral drugs and their blood routine, liver function, renal function, Items and other related indicators to understand the patient’s HBsAg concentration, HBe Ag quantitative, HBV-DNA quantitative and other conditions. Results After the treatment, 80 patients received complete response in 43 cases and non-complete response in 37 cases. HBsAg level was completely responded to patients, HBV-DNA levels were significantly lower than non-complete response (P <0.05). And there is a positive correlation between HBV-DNA and HBsAg. Conclusion The detection of serum HBsAg concentration can effectively predict the effect of antiviral drugs in patients with chronic hepatitis B, and the patients with lower serum HBsAg concentration have better virological response.