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目的：研究细胞周期调控与子宫内膜癌的关系。方法：应用免疫组化技术对45份子宫内膜癌组织中P21CIP1／WAF1蛋白和增殖细胞核抗原（PCNA）进行检测。结果：45份子宫内膜癌组织中30份（66．7％）P21CIP1／WAF1蛋白阳性，对照组均为阳性（P＜0．01）、PCNA（＋）18份，（＋＋）21份。P21CIP1／WAF1阳性率与PCNA指数呈负相关（P＜0．05）。结论：子宫内膜癌的发生与细胞周期调控有关。
Objective: To study the relationship between cell cycle regulation and endometrial cancer. Methods: The expressions of P21CIP1 / WAF1 protein and proliferating cell nuclear antigen (PCNA) in 45 endometrial carcinoma tissues were detected by immunohistochemistry. RESULTS: Thirty (66.7%) P21CIP1 / WAF1 proteins in 45 endometrial cancers were positive, while those in control group were all positive (P <0.01), PCNA (+) 18 and (++) 21. The positive rate of P21CIP1 / WAF1 was negatively correlated with PCNA index (P <0.05). Conclusion: The occurrence of endometrial carcinoma is related to the regulation of cell cycle.