论文部分内容阅读
目的探讨卵巢上皮性肿瘤中蛋白酪胺酸磷酸酶基因(PTEN)的表达及临床意义。方法采用免疫组织化学法检测PTEN在57例卵巢上皮性癌、20例卵巢良性上皮性肿瘤和10例正常卵巢组织标本中的表达。结果卵巢上皮性癌中PTEN的阳性表达率为38.6%,明显低于正常卵巢组织的100%及卵巢良性上皮性肿瘤的95.0%(P<0.05);PTEN的阳性表达率与卵巢上皮性癌的临床分期、病理分级呈负相关(P<0.05);浆液性卵巢癌中PTEN的阳性表达率为36.84%(14/38),而8例子宫内膜样卵巢癌中仅有1例表达PTEN。结论PTEN表达下调可能在卵巢上皮性癌的发生、发展中起重要作用,与子宫内膜样卵巢癌的发生关系尤为密切。
Objective To investigate the expression and clinical significance of protein tyrosine phosphatase (PTEN) in epithelial ovarian tumors. Methods Immunohistochemical method was used to detect the expression of PTEN in 57 cases of ovarian epithelial carcinoma, 20 cases of ovarian benign epithelial tumor and 10 cases of normal ovarian tissue. Results The positive expression rate of PTEN in epithelial ovarian cancer was 38.6%, which was significantly lower than that in normal ovarian tissue (95.0%) and benign epithelial ovarian tumor (95.0%) (P <0.05). The positive expression rate of PTEN correlated with the epithelial ovarian cancer (P <0.05). The positive expression rate of PTEN in serous ovarian cancer was 36.84% (14/38), while only 1 of 8 cases of endometrioid ovarian cancer expressed PTEN. Conclusions The down-regulation of PTEN expression may play an important role in the occurrence and development of epithelial ovarian cancer, which is closely related to the occurrence of endometrioid ovarian cancer.