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目的研究喉癌病人外周血Ｔ淋巴细胞亚群的分布状况及其意义。方法测定喉癌病人的外周血Ｔ淋巴细胞亚群的分布，并进行了连续观察研究。结果喉癌Ⅰ－Ⅲ期较Ⅳ期外周血Ｔ淋巴细胞亚群ＣＤ３、ＣＤ４、ＣＤ８和ＣＤ４／ＣＤ８均有显著性差异（Ｐ＜０．０５）。声门上型与声门型外周血Ｔ淋巴细胞亚群无显著性差异（Ｐ＜０．０５）。鳞状细胞癌Ⅰ－Ⅱ级较Ⅲ－Ⅳ级外周血Ｔ淋巴细胞亚群有显著性差异（Ｐ＜０．０５）。病人术后半个月外周血ＣＤ８较术前显著下降（Ｐ＜０．０５）、而ＣＤ３、ＣＤ４、ＣＤ４／ＣＤ８均无显著性差异（Ｐ＜０．０５）；术后三个月、术后半年、术后二年较术前外周血Ｔ淋巴细胞亚群ＣＤ８、ＣＤ４／ＣＤ８有显著性差异（Ｐ＜０．０５），ＣＤ３、ＣＤ４无显著性差异（Ｐ＞０．０５）。本组术后复发、转移或带癌生存的病人不同时期外周血Ｔ淋巴细胞亚群无显著性差异（Ｐ＞０．０５）。术后一年时，无癌生存者与复发、转移或带癌生存者，外周血Ｔ淋巴细胞亚群均有显著性差异（Ｐ＜０．０５）。结论连续测定喉癌病人外周血Ｔ淋巴细胞亚群，对了解病人的免疫状态，监视复发和预后有较大的临床意义。
Objective To study the distribution and significance of T lymphocyte subsets in peripheral blood of patients with laryngeal cancer. Methods The distribution of T lymphocyte subsets in peripheral blood of patients with laryngeal cancer was determined and studied continuously. Results The levels of CD3, CD4, CD8 and CD4 / CD8 of T lymphocyte subsets in stage Ⅰ-Ⅲ laryngeal cancer were significantly higher than those in stage Ⅳ (P <0.05). No significant difference was found between supraglottic and glottic T lymphocyte subsets (P <0.05). Squamous cell carcinoma Ⅰ-Ⅱ grade than Ⅲ-Ⅳ grade peripheral blood T lymphocyte subsets were significantly different (P <0.05). There was no significant difference in CD3, CD4, CD4 / CD8 between the two groups (P0.05) After 6 months, there was significant difference (P <0.05) between CD8, CD4 / CD8 and CD3, CD4 in peripheral blood T lymphocyte subsets two years after operation (P> 0.05). The recurrence, metastasis or survival of patients with T lymphocyte subsets in different periods had no significant difference (P> 0.05). One year after surgery, there was a significant difference in T lymphocyte subsets between cancer-free survival and those with recurrence, metastasis or cancer (P <0.05). Conclusion Continuous determination of T lymphocyte subsets in peripheral blood of patients with laryngeal cancer is of great clinical significance in understanding the patient’s immune status, monitoring recurrence and prognosis.