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本研究以药理学的方法检测了黄连素片对Ｃａ２＋通道的拮抗作用。结果表明黄连素片的水溶液能明显抑制Ｃａ２＋的内流．拮抗Ｌ型钙通道促进剂Ｂａｙｋ８６４４对钙通道的激活，从而降低ＳＤ大鼠胸主动脉的收缩性，４０μｇ／ｍｌ浓度的黄连素片对Ｃａ２＋通道的抑制作用与１０－８ｍｏｌ／Ｌ浓度的尼群地平相似。同时用Ｂａｙｋ８６４４使ＳＤ大鼠胸主动脉收缩后，黄连素片能以剂量依赖方式引发收缩动脉的自发性舒张。８０ｍｇ／Ｌ浓度的黄连素片能使１０－７ｍｏｌ／ＬＢａｙｋ８６４４所致的收缩血管基本达到１００％的舒张，其作用与１０－７ｍｏｌ／Ｌ的尼群地平相似。说明黄连素片具有抑制电压控制的钙通道的作用，这可能是它具有心血管药理作用的基础。
In this study, the antagonistic effect of berberine tablets on Ca2+ channels was examined by pharmacological methods. The results showed that the aqueous solution of berberine tablet significantly inhibited Ca2+ influx. Antagonizes the activation of calcium channels by Bayk8644, an L-type calcium channel accelerant, thereby reducing the contractility of thoracic aorta in SD rats. The inhibitory effect of 40μg/ml concentration of Berberine on Ca2+ channels and Nicotine concentration of 10-8mol/L The ground level is similar. Simultaneously with the use of Bayk8644 to contract the thoracic aorta in SD rats, berberine tablets can induce spontaneous relaxation of contractile arteries in a dose-dependent manner. 80mg/L concentration of berberine tablets can make 10-7mol/L Bayk8644 caused by the contraction of blood vessels basically reached 100% relaxation, its role and 10-7mol/L nitrendipine similar. It shows that berberine tablets have the effect of inhibiting voltage-controlled calcium channels, which may be the basis of its cardiovascular pharmacology.