论文部分内容阅读
目的探讨急性脑梗死(ACI)患者血小板膜糖蛋白Ⅰbα(GPⅠbα)表达与血管性血友病因子(vWF)血浆水平的变化及其与疾病临床特征的关系。方法采用流式细胞术和免疫比浊法分别检测119例ACI患者与117例健康对照者GPⅠbα的表达水平和vWF血浆水平,对不同类型ACI患者及对照组进行比较分析。结果 ACI患者外周血GPⅠbα的表达明显低于对照组,vWF的血浆水平明显高于对照组,差异均有统计学意义(P<0.05);同时合并高血压和糖尿病的ACI患者外周血GPⅠbα的表达明显高于单纯ACI患者(P<0.05)。既往有ACI病史患者外周血GPⅠbα的表达及vWF的水平与既往无ACI病史组相比差异无统计学意义(P>0.05);梗死面积大小和是否合并高血压对ACI患者GPⅠbα及vWF的血浆水平也无显著影响(P>0.05)。结论外周血GPⅠbα的表达和vWF的血浆水平可用于辅助诊断ACI;同时合并糖尿病和高血压对ACI患者外周血GPⅠbα的表达水平有显著影响。
Objective To investigate the changes of platelet glycoprotein Ⅰ bα (GP Ⅰ bα) expression and vWF plasma levels in patients with acute cerebral infarction (ACI) and its relationship with the clinical features of the disease. Methods The expression of GP Ⅰ bα and plasma vWF levels in 119 patients with ACI and 117 healthy controls were detected by flow cytometry and immunoturbidimetry. The ACI patients and controls were compared. Results The expression of GPⅠbα in peripheral blood of patients with ACI was significantly lower than that of the control group, and the plasma level of vWF was significantly higher than that of the control group (P <0.05). The GPⅠbα expression in peripheral blood of patients with ACI complicated with hypertension and diabetes mellitus Significantly higher than that of ACI patients (P <0.05). There was no significant difference in the expression of GPⅠbα and the level of vWF between the patients with previous history of ACI and those without previous history of ACI (P> 0.05). The infarct size and whether or not hypertension complicated the plasma level of GPⅠbα and vWF Also had no significant effect (P> 0.05). Conclusion The expression of GP Ⅰ bα in peripheral blood and vWF plasma level can be used to diagnose ACI. The combination of diabetes mellitus and hypertension has a significant effect on the expression of GP Ⅰ bα in peripheral blood of patients with ACI.