Survivin是一种既可调控细胞分裂,也可抑制细胞凋亡的蛋白,Bcl-2是抑制细胞凋亡的基因,细胞周期蛋白(Cyclin D1)是细胞有丝分裂过程中的一种细胞周期调控因子,本文就Survivin、Cyclin D1和Bcl-2的结构和功能特点、作用机制及在乳腺良恶性病变中的表达特点及其意义作一简要综述。 Survivin is a protein that can regulate both cell division and apoptosis. Bcl-2 is a gene that inhibits apoptosis. Cyclin D1 is a cell cycle regulatory factor in cell mitosis, This review summarizes the structural and functional characteristics of Survivin, Cyclin D1 and Bcl-2, their mechanism of action and their expression in benign and malignant breast lesions.