胎儿微嵌合体广泛存在于妊娠妇女体内,尽管胎儿微嵌合体形成的具体机制尚不明确,但是近年来各国学者在胎儿微嵌合体对母体的影响方面做了大量研究,发现胎儿微嵌合体的异常可能与子痫前期等妊娠并发症及不良妊娠结局有关。自身免疫性疾病易发生于育龄妇女且易在妊娠期恶化,胎儿微嵌合体可能参与自身免疫性疾病的发生发展过程。因胎儿微嵌合体携带母亲所不具有的等位基因,使其对抗母体肿瘤方面发挥保护性作用。此外,胎儿微嵌合体可能参与组织损伤后的修复过程。 Fetal microchimerism is widely found in pregnant women, although the specific mechanism of fetal microchimerism formation is not clear, but in recent years, scholars from all over the world have done a lot of research on the impact of fetus microchimerism and found that fetal microchimerism Abnormalities may be related to pregnancy complications such as preeclampsia and adverse pregnancy outcomes. Autoimmune diseases occur in women of childbearing age and tend to worsen during pregnancy, and fetal microchimerism may be involved in the development of autoimmune diseases. Fetal chimera carries a protective effect against maternal tumors because it carries alleles not present in the mother. In addition, fetal microchimerism may be involved in the repair process after tissue injury.