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雌激素维护骨代谢，并抑制淋巴细胞免疫功能。以５０ＧｙＸ射线局部照射大鼠卵巢，造成卵泡闭锁、雌二醇（Ｅ２）低下，并致尿Ｃａ／ｃｒ（钙／肌肝）、ＨＯＰ／ｃｒ（羟脯氨酸／肌肝）和血ＡＬＰ（碱性磷酸酶）升高，骨小梁数和面积减小，淋巴细胞增殖和分泌ＩＬ－２的活性增加。淋巴细胞分泌ＩＬ－２的活性与血Ｅ２水平是显著负相关，２４ｈ尿Ｃａ量与淋巴细胞分泌ＩＬ－２的活性呈显著正相关。表明卵巢电高辐射效应对骨代谢和淋巴细胞免疫功能有明显影响，ＩＬ－２在雌激素对骨代谢的影响中可能起介导作用。
Estrogen maintains bone metabolism and suppresses lymphocyte immune function. Local ovarian irradiation with 50Gy X-ray resulted in atresia of follicles, low estradiol (E2) and urinary Ca / cr (calcium / muscle liver), HOP / cr Alkaline phosphatase) increased trabecular number and area decreased lymphocyte proliferation and secretion of IL-2 activity increased. The activity of IL-2 secreted by lymphocytes was negatively correlated with the level of serum E2. There was a significant positive correlation between the level of urinary Ca and the secretion of IL-2 by lymphocytes. The results suggest that the high radiation effect of ovaries has a significant effect on bone metabolism and lymphocyte immune function. IL-2 may play a mediating role in the effect of estrogen on bone metabolism.