大肠杆菌是小儿夏秋季腹泻的重要致病菌,因常对多种抗生素耐药而造成治疗困难。我科自1993年根据药敏采用氧氟沙星治疗52例多重耐药的侵袭性大肠杆菌肠炎。年龄～1岁14例,～3岁38例。临床均有发热与脓血便。大便细菌培养均为大肠杆菌O_(112),体外药敏对氨苄青、丁胺卡那、小诺霉素、先锋V、吡哌酸不敏感;氟哌酸、头孢噻肟钠低敏感;氧 Escherichia coli is an important pathogenic bacteria in children with summer and autumn diarrhea, often due to a variety of antibiotic resistance caused by treatment difficulties. In our department since 1993, ofloxacin 52 cases of multi-drug-resistant invasive E. coli enteritis. Age ~ 1 year old 14 cases, ~ 3 years old 38 cases. Clinical fever and pus and blood. Stool bacterial culture were Escherichia coli O_ (112), in vitro susceptibility to ampicillin, amikacin, minocycline, vanguard V, pipemidic acid insensitivity; norfloxacin, cefotaxime sodium is low sensitivity; oxygen