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目的 :评价金蒲抑瘤片对小鼠药效及毒性作用。方法 :用 NIH小鼠分组试验 ,接种瘤株为肉瘤 S1 80 和肝癌 H2 2 ,灌胃给药 ,观察相关指标。结果 :金蒲抑瘤片能抑制小鼠肉瘤 S1 80 和小鼠肝癌 H2 2 实体瘤的生长 ,平均抑瘤率分别为 4 3.6 %和 2 6 .2 % ;能延长腹腔积液型肝癌和 S1 80 腹腔积液型小鼠的生存时间 ,平均生命延长率分别为 6 0 .9%和 2 9.7%。并能增强免疫功能低下的荷瘤小鼠的碳粒廓清指数和半数溶血值 ,升高荷瘤小鼠的白细胞数 ,减轻环磷酰胺对小鼠白细胞的毒性 ,提高热板致痛小鼠的痛阈值。急性毒性和长期毒性试验 ,表明毒性反应低 ,使用安全。结论 :本品具有活血祛瘀 ,行气止痛 ,抑瘤减毒 ,增强免疫功能等作用
Objective: To evaluate the efficacy and toxicity of Jinpu Xiaoliu Tablet on mice. METHODS: The NIH mice were divided into groups and the tumors were inoculated with sarcoma S1 80 and H2 2 , and were intragastrically administered to observe the relevant indicators. RESULTS: Jinpu Xiaoliu Tablets inhibited the growth of mouse sarcoma S1 80 and mouse hepatoma H2 2 solid tumors, and the average tumor inhibition rates were 4 3.6 % and 2 6.2% respectively; they were able to prolong the peritoneal effusion and S1 The survival time of 80 peritoneal effusion mice, the average life extension rate was 60.9% and 29.7% respectively. And can enhance the immunocompromised tumor-bearing mice’s carbon clearance index and half hemolytic value, increase the number of white blood cells in tumor-bearing mice, reduce the toxicity of cyclophosphamide on mouse leukocytes, and improve the hot plate induced pain in mice Pain threshold. Acute toxicity and long-term toxicity tests showed that the toxicity was low and the use was safe. Conclusion : This product has the functions of promoting blood circulation, relieving pain and attenuating tumor, enhancing immune function and so on.