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目的探讨盐酸乙哌立松联合舍曲林治疗慢性紧张型头痛疗效及安全性。方法选取2013年6月至2016年6月期间我院神经内科收治的慢性紧张型头痛80例患者作为研究对象,采用随机数字、平行法将所有患者分为治疗组和对照组,每组患者各40例,治疗组患者予以餐后服用盐酸乙哌立松联合舍曲林进行治疗,对照患者仅予以餐后口服盐酸乙哌立松,观察两组患者治疗效果及不良反应。结果治疗组患者临床控制和总有效率分别为52.50%、92.50%明显较对照组的30.00%、75.00%高,行χ~2检验,P<0.05,治疗组5(12.50%)例患者,对照组4(10.00%)例发生嗜睡、头晕、轻度肢体乏力及胃肠道反应等不良反应,均可难受无需治疗,两组差异不明显(P>0.05)。结论盐酸乙哌立松与舍曲林联合治疗慢性紧张型头痛疗效确切且不良反应少,临床应用前景广阔。
Objective To investigate the efficacy and safety of Eperisone Hydrochloride Combined with Sertraline in the treatment of chronic tension-type headache. Methods Eighty patients with chronic tension-type headache admitted from June 2013 to June 2016 in our department of neurology were selected as research objects. All patients were divided into treatment group and control group by random number and parallel method. Forty patients in the treatment group were treated with Eperisone Hydrochloride combined with sertraline after the meal. Patients in the control group were given oral Eperisone Hydrochloride only after meals. The therapeutic effect and adverse reactions of the two groups were observed. Results The clinical control and total effective rate of the treatment group were 52.50% and 92.50% respectively, which were significantly higher than those of the control group (30.00% and 75.00%, respectively) Patients in group 4 (10.00%) developed drowsiness, dizziness, mild limb weakness and gastrointestinal reactions, which were not affected by treatment. There was no significant difference between the two groups (P> 0.05). Conclusion Eperisone hydrochloride combined with sertraline is effective in treating chronic tension-type headache and has few adverse reactions. It has a bright future in clinical application.