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目的 :观察小剂量尼尔雌醇对绝经后冠心病患者血浆内皮素、一氧化氮及血浆纤溶活性的影响。方法 :30例患者在常规治疗基础上加用小剂量尼尔雌醇 ,观察治疗前后血浆内皮素、一氧化氮及血浆纤溶活性的变化。结果 :血浆一氧化氮、组织型纤溶酶原激活物活性显著升高 (P <0 .0 1) ,血浆内皮素、纤溶酶原激活物抑制物活性降低 (P <0 .0 5 )。结论 :尼尔雌醇可以改善内皮细胞功能和纤溶活性 ,可作为绝经后妇女单一预防冠心病的药物
Objective: To observe the effects of low-dose nilestriol on plasma endothelin, nitric oxide and plasma fibrinolytic activity in postmenopausal women with coronary heart disease. Methods: Thirty patients were treated with low dose nilestriol on the basis of routine treatment. The changes of plasma endothelin, nitric oxide and plasma fibrinolytic activity were observed before and after treatment. Results: Plasma nitric oxide, tissue plasminogen activator activity were significantly increased (P <0.01), plasma endothelin, plasminogen activator inhibitor activity decreased (P <0.05) . Conclusion: Nylestriol can improve the function of endothelial cells and fibrinolytic activity and can be used as a single anti-coronary drug in postmenopausal women