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腺样体肥大(AV)是儿童常见疾病,因咽扁桃体与鼻咽部粘膜的淋巴滤泡发生增生肥大所致,咽扁桃体做为咽淋巴内环的组成部分,具有与中央、外周淋巴器官相似的免疫调节性能.儿童因鼻咽部反复发生急性或亚急性炎症而致腺样体肥大,其免疫功能受到影响。近年来的研究表明,细胞因子参与了腺样体、扁桃体疾病的免疫机制。本研究检测了AV儿童血清IL-2、sIL-2R、TNF-α的水平,从细胞和受体水平进一步探讨AV对儿童免疫功能的影响。
Adenoid hypertrophy (AV) is a common disease in children, due to pharyngeal tonsils and nasopharyngeal mucosa caused by lymphoid follicles hyperplasia hypertrophy caused by pharyngeal tonsil as part of the pharyngeal lymphoid ring, with the central and peripheral lymphoid organs similar Of immunomodulatory performance in children due to repeated nasopharyngeal acute or subacute inflammation caused adenoid hypertrophy, immune function is affected. Recent studies have shown that cytokines are involved in the immune mechanisms of adenoid and tonsil diseases. This study examined the levels of serum IL-2, sIL-2R and TNF-α in children with AV and further explored the effects of AV on immune function in children from cellular and receptor levels.