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目的观察局部晚期食管癌行同步放化疗的近期治疗效果。方法选取2011年11月至2013年1月进入我院治疗的局部晚期食管癌患者142例,随机将其分为观察组组和对照组,每组各71例。给予对照组患者单纯放射治疗,观察组患者在对照组的放疗基础上同步实施氟尿嘧啶+顺铂静脉滴注化疗,观察比较两组患者的近期治疗效果以及不良反应情况。结果观察组治疗总有效率为85.9%,对照组中有效率为60.5%,两组总有效率相比差异具有统计学意义(P<0.05)。观察组血小板减少、白细胞减少、恶心、呕吐、肝功能异常、肾功能异常、变态反应、贫血、脱发不良反应率均高于于对照组,但两组发生情况比较差异均无统计学意义(P>0.05)。结论同步放化疗治疗局部晚期食管癌的效果优于单纯使用放疗治疗局部晚期食管癌的效果,且安全可行,值得临床推广使用。
Objective To observe the recent therapeutic effect of concurrent chemoradiotherapy in locally advanced esophageal cancer. Methods 142 patients with locally advanced esophageal cancer who entered our hospital from November 2011 to January 2013 were randomly divided into observation group and control group, with 71 cases in each group. The patients in the control group received radiotherapy alone. The patients in the observation group received concurrent chemotherapy with fluorouracil plus cisplatin intravenously on the basis of radiotherapy in the control group. The treatment effect and adverse reactions of the two groups were observed and compared. Results The total effective rate was 85.9% in the observation group and 60.5% in the control group. The total effective rate in the two groups was statistically significant (P <0.05). The observation group thrombocytopenia, leukopenia, nausea, vomiting, abnormal liver function, renal dysfunction, allergy, anemia, hair loss adverse reactions were higher than the control group, but there was no significant difference between the two groups (P > 0.05). Conclusions The efficacy of concurrent chemoradiotherapy in the treatment of locally advanced esophageal cancer is superior to that of locally advanced esophageal cancer treated with radiotherapy alone and is safe and feasible. It is worthy of clinical application.