目的分析1例原发性侵袭性声带曲菌病的诱因、临床、病理学特征、诊断及治疗。方法回顾性分析广州呼吸疾病研究所收治的1例原发性侵袭性声带曲菌病的诱因、临床、影像学、病理资料及诊断,并复习相关文献。结果该例患者为年轻女性,无明显诱因,经纤支镜活检病理证实为声带曲菌病。临床表现仅为声音嘶哑、失声,经伊曲康唑、二性霉素B抗真菌治疗后症状完全缓解。结论原发性侵袭性曲霉菌病可无明显诱因,由于症状、体征均不典型,容易误诊,早期鉴别诊断具有重要意义,确诊需感染的组织病理学证据,首选伊曲康唑治疗。 Objective To analyze the causes, clinical and pathological features, diagnosis and treatment of one case of primary invasive candidal aspergillosis. Methods A retrospective analysis of the Guangzhou Institute of Respiratory Diseases in 1 case of primary invasive invasive aspergillosis of the causes, clinical, imaging, pathological data and diagnosis, and review the relevant literature. Results The patients were young women, no obvious incentive, confirmed by pathological bronchoscopy biopsy. Clinical manifestations were only hoarseness, vocal, and after itraconazole, amphotericin B antifungal therapy symptoms completely relieved. Conclusion Primary invasive aspergillosis may have no obvious inducement. Because the symptoms and signs are not typical, it is easy to be misdiagnosed. Early differential diagnosis is of great significance. The histopathological evidence of infection is confirmed, and itraconazole is the preferred treatment.