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背景:苦瓜属植物提取物有降糖效果是已被证实的,而其是否有调脂作用还需进一步研究。目的:评价苦瓜降糖胶囊对老年2型糖尿病的降糖及调脂作用。设计:前后对照试验。地点、对象和方法:研究对象为2003-03收集的35例男性2型糖尿病患者,年龄70～86岁,平均(77±5)岁。纳入研究对象均为军队干休所离退休干部;既往均明确诊断为2型糖尿病,即符合1985年世界卫生组织2型糖尿病诊断标准;所有患者1个月未用过胰岛素及口服降糖药物。排除患有其他严重的躯体性疾病;有精神疾病或精神疾病家族史;有严重智力或认知障碍患者。对35例患者投入的药物为本院制备的苦瓜降糖胶囊。每例患者均在疗程前后立即检测空腹血糖、餐后2h血糖、糖化血红蛋白和血脂。血糖测定为酶试剂法。糖化血红蛋白采用微柱法。总胆固醇、三酰甘油、高密度脂蛋白胆固醇均用酶法。主要观察指标:用药前后的血糖、血脂的变化。结果:采用苦瓜降糖胶囊治疗后患者空腹血糖,餐后2h血糖及糖化血红蛋白犤(5.02±1.67),(9.70±3.44)mmol/L,(5.79±1.18)%犦均有较治疗前犤(7.59±1.83),(12.63±3.65)mmol/L,(6.33±1.28)%犦明显下降(t=14.496,8.493,4.644,P<0.01)。总有效率分别为94%(33/35),80%(28/35),80%(28/35)。治疗后胆固醇、三酰甘油有明显下降(t=12.400,7
BACKGROUND: Momordica extract has been hypoglycemic effect has been confirmed, and whether its role in lipid regulation needs further study. Objective: To evaluate the hypoglycemic effect and lipid-lowering effect of bitter melon hypoglycemic capsule on senile type 2 diabetes mellitus. Design: Control before and after the test. Location, Subjects and Methods: The subjects were 35 male patients with type 2 diabetes mellitus who were collected from 2003-03. The patients were 70 to 86 years old with mean of 77 ± 5 years. All subjects included in the study were all retired cadres who had been on duty in the military. All of them were diagnosed with type 2 diabetes in the past, that is, they were in line with the WHO diagnostic criteria for type 2 diabetes in 1985. All patients had not used insulin and oral antidiabetic drugs for 1 month. Exclude other serious physical diseases; have a family history of mental illness or mental illness; patients with severe mental or cognitive disorders. To 35 patients in the medicine for the preparation of bitter melon hypoglycemic capsules. Fasting blood glucose, fasting blood glucose, glycosylated hemoglobin and lipids were measured immediately before and after treatment in each patient. Blood glucose test for the enzyme reagent. Glycosylated hemoglobin using micro-column method. Total cholesterol, triglyceride, high-density lipoprotein cholesterol are enzymatic. MAIN OUTCOME MEASURES: Changes in blood glucose and blood lipids before and after treatment. Results: The fasting blood glucose, postprandial 2h blood glucose and glycosylated hemoglobin 犤 (5.02 ± 1.67), (9.70 ± 3.44) mmol / L and (5.79 ± 1.18)% 采were significantly higher than those before treatment 7.59 ± 1.83), (12.63 ± 3.65) mmol / L, (6.33 ± 1.28)% 犦 (t = 14.496,8.493,4.644, P <0.01). The total effective rates were 94% (33/35), 80% (28/35) and 80% (28/35) respectively. After treatment, cholesterol, triglyceride decreased significantly (t = 12.400,7