0引言大量研究表明,传统肿瘤治疗多直接针对肿瘤细胞而存在很多缺陷,如容易产生肿瘤耐药性、药物不易进入肿瘤细胞内部等。1971年哈佛大学Folk-man教授[1]提出实体肿瘤的生长和转移依赖于新生血管生成的观点后,国内外研究者做了大量深入研究,并取得了较大进展,使抑制或破坏肿瘤 0 Introduction A large number of studies have shown that many of the traditional tumor treatment directly against tumor cells and there are many shortcomings, such as prone to tumor drug resistance, drugs are not easy to enter the interior of tumor cells. After Professor Folk-man of Harvard University [19] put forward the viewpoint that the growth and metastasis of solid tumors are dependent on neovascularization in 1971, researchers at home and abroad made a lot of in-depth studies and made great progress to inhibit or destroy the tumors