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本文报道云南药用乌头属植物中乌头碱型二萜生物碱乌头碱(aconitine,1),滇乌碱(yunaconitine,3),黄草乌碱甲(vilmorrianine A,5)、碱乙(vilmorrianine B,即karakoline,8)、碱丙(vilmorrianine C,7)、碱丁(vilmorrianine D,9)和鹤乌碱(scopaline,10)及3-乙酰乌头碱(2),3-乙酰滇乌碱(4)和3-乙酰黄草乌碱甲(6)的~(13)C核磁共振谱。根据偏共振去偶及取代基加和律计算,并与类似物比较,对这些化合物各碳原子的共振讯号给予了指定,且进一步确定了新生物碱3,5,7,9的结构。对1,3,5,8及2,4,6中的羟基和乙酰基取代效应也作了分析,并通过对1,3,5及2,4,6的比较而修正了Pelletier对1中C_2和C_(12)化学位移的指定。还证明8中因C_1为α-OH而形成分子内氢键,使A环呈船式构型,所以A环上碳的化学位移与一般的椅式构型有显著差异。本文还报道了从鹤庆紫草乌(Aconitum episcopale Levl.)中分到的一新生物碱——鹤乌碱(scopaline)。根据红外光谱、质谱及~1H和~(13)C核磁共振谱,确定其结构为10。
This paper reports the aconitine aconitine (1), yaconitine (3), vilmorrianine A (5), alkali B (vilmorrianine B, ie karakoline, 8), vilmorrianine C (7), vilmorrianine D (9) and scopaline (10) and 3- acetaaconitine (2) ~ (13) C Nuclear Magnetic Resonance Spectroscopy of Dianlukali (4) and 3-Acetylxanthone A (6). The resonance signals of each carbon atom of these compounds are assigned according to the addition and subtraction of partial resonance and the law of additive law, and the structures of the new alkaloids 3,5,7,9 are further confirmed. The substitution effects of hydroxyl and acetyl groups in 1,3,5,8 and 2,4,6 were also analyzed and the Pelletier pair 1 was modified by comparing 1,3,5 and 2,4,6 C_2 and C_ (12) chemical shift designation. It has also been shown that due to intramolecular hydrogen bonding due to the C-1 alpha-OH in 8, the A ring is in a boat-like configuration so that the chemical shift of the carbon in the A ring is significantly different from the general chair configuration. We also report a new alkaloid, scopaline, from Aconitum episcopale Levl. The structure was confirmed to be 10 by IR, MS and ~ 1H and ~ (13) C NMR spectra.