鼻腔及鼻窦肠型腺癌的临床病理学特点

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原发于鼻腔及鼻窦的肠型腺癌非常罕见,患者的发病年龄范围较广,50~60岁为发病高峰。肿瘤可位于筛窦、鼻腔及上颌窦等处。镜下见肿瘤的特点为瘤细胞排列成乳头状、腺样及实性巢状等,在瘤细胞内、外常有多量黏液,表现为可见杯状细胞、印戒样瘤细胞及黏液湖等。肠型腺癌应与多种其他肿瘤相鉴别,肿瘤具有局部侵袭性,并可发生颈部淋巴结及远处转移。对肿瘤的治疗方法主要为手术切除,在术后可以行放疗。对手术切除肿瘤困难者可先给予化疗。 Primary nasal and sinus gut type of adenocarcinoma is very rare, the patient’s onset of a wide range of ages, 50 to 60-year-old peak incidence. Tumors can be located in the ethmoid, nasal and maxillary sinus and other places. Microscopically see the tumor is characterized by tumor cells arranged in papillary, adenoid and solid nests, etc., in the tumor cells often have a large number of mucus, showed as goblet cells, signet-ring like tumor cells and mucous lake . Enteric-type adenocarcinoma should be differentiated from a variety of other tumors that have local invasiveness and may have cervical lymph nodes and distant metastases. The treatment of tumors mainly for surgical resection, radiotherapy can be performed after surgery. Chemotherapy can be given to patients who have surgical excision of the tumor.
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研究背景与目的:   肿瘤的脉管系统是新一代抗癌药“攻击”的靶点。靶向肿瘤血管的治疗手段分为抑制肿瘤血管的生成(血管生成抑制剂)和破坏已经形成的血管(血管阻断剂)。血