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近年来,在药物制剂的研究和生产中,针对治疗上的需要,利用辅料和剂型控制药物体内释放与转运以达到给药精密化,出现了许多新型辅料和新的给药系统。新型辅料特别是合成高分子聚合物的不断涌现,为剂型改进与创新提供了丰富的物质基础。本文对辅料的作用包括辅料与剂型结构的关系、辅料对药物体内吸收与分布的影响、以及对某些新型辅料的特点及其应用等作了概要介绍。
In recent years, in the research and production of pharmaceutical preparations, new materials and new drug delivery systems have emerged due to the need of treatment, the use of excipients and dosage forms to control in vivo drug release and transport in order to achieve the precision of drug delivery. New materials, especially synthetic polymers continue to emerge, providing a rich material basis for the improvement and innovation of dosage forms. In this paper, the role of excipients including the relationship between excipients and dosage form structure, excipients on the absorption and distribution of drugs, as well as some of the characteristics of new excipients and their applications are briefly introduced.