目的研究人体乳腺癌浸润部位对其电阻抗频谱特性的影响,为乳腺电阻抗扫描成像仪器检查结果中出现“暗区”现象提供实验依据和基础数据。方法依据乳腺癌浸润部位不同分为2组:浸润到脂肪组和浸润到腺体组,采用英国Solartron公司1255B型频响分析仪,四电极法离体测量组织电阻抗频谱特性,测量频率1Hz~1MHz。采用非线性曲线拟合的方法得到cole-cole模型参数。结果从电阻抗特性实部看,浸润到脂肪组中乳腺癌的电阻率大大低于周围脂肪组织;而浸润到腺体组的乳腺癌组织的电阻率高于周围腺体组织;从电阻抗特性虚部看,各种测量组织的特征频率有所不同:脂肪组织的特征频率在1kHz左右,乳腺癌组织在200k~300kHz;腺体组织为2k~3kHz。结论无论是测量数据还是模型参数,乳腺癌及其周围组织的电阻抗特性存在显著性差异,同时发现癌组织浸润的部位不同,其差异有所不同。 Objective To study the influence of infiltrated parts of human breast on the electrical impedance characteristics of electrical resistance and to provide experimental basis and basic data for the appearance of “dark area” in the examination results of breast electrical impedance scanning imaging equipment. The method was divided into two groups according to the infiltrating site of breast cancer: infiltrating into the adipose tissue and infiltrating into the gland group. Using the frequency analyzer 1255B of Solartron Company of UK, the four-electrode method was used to measure the tissue impedance characteristic spectrum in vitro. The measurement frequency was 1Hz ~ 1MHz. The cole-cole model parameters were obtained by nonlinear curve fitting. Results From the real part of the electrical impedance characteristics, the resistivity of breast cancer infiltrating into the fat group was significantly lower than that of the surrounding adipose tissue; while the resistivity of the breast cancer tissue infiltrating into the gland group was higher than that of the surrounding gland tissue; The imaginary part of the view, a variety of measurement of the characteristic frequency of the tissue is different: the characteristic frequency of adipose tissue about 1kHz, breast cancer tissue at 200k ~ 300kHz; gland tissue 2k ~ 3kHz. Conclusion There is a significant difference in the electrical impedance characteristics between breast cancer and its surrounding tissues, both in the measurement data and the model parameters. The differences in the locations of the invasive tissues of breast cancer and their surrounding tissues are also different.