核糖核酸酶〔ribonuclease ,RNase〕是一类能够特异性切割RNA的酶 ,既有催化活性 ,又有细胞毒性。它们的生物学活性由激动剂和抑制剂所控制。迄今为止 ,已分离纯化出多种不同种类的RNase ,并对其结构和功能进行了深入的研究。研究表明 ,其中BS RNase、Onconase和RC RNase等具有抗肿瘤作用 ,可作为细胞毒素进入肿瘤细胞 ,抑制肿瘤细胞的生长 ,因此RNase的研究为临床治疗肿瘤提供了新的前景 ,有望成为一类新型的抗肿瘤药物 Ribozymes (ribonuclease, RNase) is a class of enzymes that can specifically cleave RNA, both catalytic and cytotoxic. Their biological activity is controlled by agonists and inhibitors. So far, many different kinds of RNases have been isolated and purified, and their structures and functions have been deeply studied. Studies have shown that, among them, BS RNase, Onconase and RC RNase have anti-tumor effect and can enter into tumor cells as cytotoxins and inhibit the growth of tumor cells. Therefore, the research of RNase provides a new prospect for the clinical treatment of tumors and is expected to become a new type Anti-cancer drugs