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目的观察血管紧张素转换酶抑制剂赖诺普利与醛固酮拮抗剂安体舒通联合治疗高血压性心力衰竭的安全性和有效性。方法40例高血压性心力衰竭患者同时服用赖诺普利10mg,每日1次,安体舒通20~80mg,每日1~3次,经8周治疗后观察血压及心功能改善情况。结果全部患者的收缩压和舒张压均降低(P<0.01),降压总有效率为90.0%,心功能改善有效率为95.0%,其中显效70.0%,有效25.0%,且血钾无严重增高。结论赖诺普利与安体舒通联合治疗高血压性心力衰竭安全、有效。
Objective To observe the safety and efficacy of the combination of angiotensin converting enzyme inhibitor lisinopril and aldosterone antagonist spironolactone in the treatment of patients with congestive heart failure. Methods Forty hypertensive patients with heart failure were treated with lisinopril 10 mg once daily and spironolactone 20 ~ 80 mg once or three times a day. The improvement of blood pressure and heart function were observed after 8 weeks of treatment. Results The systolic pressure and diastolic pressure were decreased in all patients (P <0.01). The total effective rate was 90.0%, the effective rate of heart function improvement was 95.0%, of which 70.0% was markedly effective and 25.0% effective, with no significant increase of serum potassium . Conclusion The combination of lisinopril and spironolactone in the treatment of hypertensive heart failure is safe and effective.