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目的研究持续小剂量西地那非治疗早泄(PE)对良性前列腺增生症(BPH)引起的下尿路症状(LUTS)的影响。方法 82例PE同时伴有BPH的研究对象,随机分为2组,分别服用为期3个月的小剂量西地那非(A组)和左洛复(B组)。在治疗前后行中国早泄指数评估表(CIPE)、国际前列腺症状评分表(IPSS)评分,比较其治疗前、后CIPE和IPSS评分。结果治疗后A组CIPE明显增高,IPSS评分明显下降(P<0.01);B组CIPE明显增高(P<0.01),但IPSS评分轻度下降(P>0.05)。结论治疗中老年性PE合并BPH,小剂量西地那非既能有效治疗PE,又能改善由BPH引起的LUFS症状。
Objective To investigate the effect of continuous low-dose sildenafil treatment on lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH) in premature ejaculation (PE). Methods Eighty-two PE patients with BPH were randomly divided into two groups. The three groups were given low-dose sildenafil (group A) and Zoloft (group B) respectively. CIPE and IPSS scores before and after treatment were compared before and after CIPE and IPSS scores. Results After treatment, the CIPE of group A was significantly increased, and the score of IPSS was significantly decreased (P <0.01). The CIPE of group B was significantly increased (P <0.01), but the score of IPSS decreased slightly (P> 0.05). Conclusion Treatment of middle-aged and elderly PE with BPH, low-dose sildenafil both effective treatment of PE, but also to improve the LUFS symptoms caused by BPH.