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本文对照研究了脑出血患者血浆及脑脊液（ＣＳＦ）内皮素－１（ＥＴ－１）含量改变及其临床意义。发现脑出血患者血浆与ＣＳＦ、ＥＴ－１含量均增高；单纯脑血肿者以血浆含量增高为主；脑实质出血伴有脑室系统或蛛网膜下腔出血（ＳＡＨ）者血浆及ＣＳＦ含量均显著升高；小量出血与中大量出血比较血浆含量无显著性，而大量出血者ＣＳＦ、ＥＴ－１含量增高。提示脑出血者血浆ＥＴ－１增高可能与机体应激有关，而ＣＳＦ、ＥＴ－１升高可能与血脑屏障（ＢＢＢ）被破坏及损害或刺激室周组织、下丘脑、脉络丛脑膜，引起分泌释放增加有关。ＣＳＦ、ＥＴ－１增高者应警惕迟发性脑血管痉挛。
In this paper, we investigated the changes of endothelin-1 (ET-1) in plasma and cerebrospinal fluid (CSF) in patients with intracerebral hemorrhage and its clinical significance. The levels of plasma and CSF and ET-1 in patients with intracerebral hemorrhage were significantly higher than those in patients with cerebral hemorrhage. Plasma levels of CSF and plasma CSF were significantly increased in patients with cerebral hemorrhage accompanied with ventricular system or subarachnoid hemorrhage (SAH) High; a small amount of bleeding compared with a large amount of bleeding was not significant plasma levels, while a large number of bleeding CSF, ET-1 levels increased. It is suggested that the increase of plasma ET-1 in ICH patients may be related to the stress in the body, while the elevated levels of CSF and ET-1 may be associated with the destruction of the BBB and damage or stimulation of periventricular tissues, hypothalamus and choroid plexus, Increased secretion of secretion related. CSF, ET-1 increased should be alert to delayed cerebral vasospasm.