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目的探讨T2DM患者正常范围内血清丙氨酸氨基转移酶(ALT)水平与MS的相关性。方法选取319例ALT水平正常的T2DM患者按四分位数分为4组(Q1～4组),分析ALT水平与MS组间差异及其组分的关系。结果随ALT水平升高,T2DM患者BMI、TG、SUA和胰岛素抵抗指数(HOMA-IR)均逐渐升高(趋势P<0.05),且TG、HOMA-IR与ALT呈独立相关;MS、肥胖、高甘油三酯血症的患病率随ALT的升高而升高(趋势P<0.001)。Q1～4组,MS患病率分别为41.5%、47.2%、54.9%和65.9%。ALT水平与MS及其多数组分的患病风险有相关性。与Q1组比,Q4组MS患病风险增加232%,肥胖风险增加138%,高血压风险增加175%,高甘油三酯血症风险增加256%。结论 T2DM患者正常范围内血清ALT水平与MS及其组分密切相关。
Objective To investigate the correlation between the levels of serum alanine aminotransferase (ALT) and MS in the normal range of T2DM patients. Methods 319 T2DM patients with normal ALT level were divided into 4 groups according to quartiles (Q1 ~ 4), and the relationship between ALT level and the differences among MS groups and their components were analyzed. Results The levels of BMI, TG, SUA and insulin resistance index (HOMA-IR) in T2DM patients increased gradually with increasing ALT level (trend P <0.05), and TG and HOMA- The prevalence of hypertriglyceridemia increased with increasing ALT (trend P <0.001). The prevalence rates of MS in Q1 ~ 4 groups were 41.5%, 47.2%, 54.9% and 65.9% respectively. The level of ALT correlates with the prevalence of MS and most of its components. Compared with the Q1 group, Q4 increased the risk of MS by 232%, increased the risk of obesity by 138%, increased the risk of hypertension by 175% and the risk of hypertriglyceridemia by 256%. Conclusion The level of serum ALT in the normal range of T2DM patients is closely related to MS and its components.